A woman sits on a gray sofa, wrapped in a blanket, with her head resting on her hand in a pensive or sad pose

Magnesium for Migraines UK: A Guide to Using Magnesium Citrate for Relief

Migraine isn't just a bad headache it's a complex neurological condition that can be debilitating. In fact, migraines affect around 6 million people in the UK [1], making migraine relief a top priority for many. While conventional treatments (like painkillers, triptans, and other prescription medications) are available, they don't work for everyone and may cause side effects. This has led countless sufferers to seek out natural migraine remedies. Among these natural migraines remedies, one option stands out for its promising benefits and safety: magnesium. In particular, magnesium citrate a well-absorbed form of magnesium has gained popularity as a supplement for migraine prevention and relief. In this comprehensive guide, we'll explore why magnesium for migraines is recommended, what the science says, how to use it (including dosage recommendations), and what UK health sources like the NHS and migraine experts advise. Our goal is to provide an expert yet humanized look at magnesium citrate as a tool for migraine relief, so you can make informed decisions on your journey to fewer headaches and a better life.

Jump to our pillar explainer for forms, benefits and dosing: Magnesium Supplements UK Guide »


Migraines in the UK and the Search for Relief

Migraines are more than just throbbing pain - they often come with nausea, sensory sensitivities, and even visual or neurological disturbances (aura). These episodes can last for hours or days, disrupting work and quality of life. In the UK, migraines are a leading cause of disability for people under 50, and they disproportionately affect women. The NHS notes that migraines are very common, impacting about 1 in every 7 people (roughly six million Britons) [1]. Sufferers may experience attacks several times a month, and menstrual migraines (attacks linked to periods) are also frequent [5].

Standard treatment focuses on acute relief (painkillers, anti-nausea medicine, triptans) and preventive drugs for frequent attacks (like beta-blockers or anti-seizure medications). However, not everyone responds well to these medications, and some endure side effects or contraindications. This has fostered interest in complementary and natural migraine remedies that might help either in place of or alongside standard care. Natural migraines remedies often include lifestyle changes (diet, stress management, sleep hygiene) and nutraceutical supplements. The National Migraine Centre (UK) explains that many vitamins, minerals, and herbal supplements have been tried over the years for migraine prevention - though research is limited, some natural remedies for headaches have shown effectiveness to a degree [2]. People drawn to these approaches may prefer to avoid additional prescription drugs or seek an extra edge in preventing attacks.

One of the most popular and well-studied natural options is magnesium. Magnesium is a mineral naturally present in foods like leafy greens, nuts, seeds, and whole grains, and it's critical for numerous bodily functions. Because of its role in nerve and muscle function, energy production, and blood pressure regulation, magnesium has attracted attention as a potential natural remedy for migraine relief. Both patients and healthcare providers have begun asking: can boosting magnesium help with migraines? In the UK, organizations like The Migraine Trust and the NHS have started to acknowledge magnesium as a supplemental option for migraine prevention [3][4]. Before diving into how to use magnesium, let's look at why it might work.

Why Magnesium? Understanding Its Role in Migraine Relief

Magnesium isn't some exotic new cure it's an essential mineral that our bodies need to function properly. So, why the interest in magnesium for migraines specifically? Research over the past few decades has uncovered several compelling connections between magnesium levels and migraine.

First, migraine sufferers often have low magnesium levels in various measurements. Studies have found that a significant number of people who get migraines show signs of magnesium deficiency. For example, researchers have observed low magnesium in the brain and bloodstream of migraine patients during attacks [2]. One study cited by a 2025 review found that people with low serum magnesium had a dramatically higher risk of headaches in fact, low magnesium was associated with a 35-fold increase in the likelihood of acute migraine headaches [5]. That suggests magnesium deficiency could be a key risk factor for migraines, at least in some individuals.

Why would magnesium make such a difference? Magnesium is deeply involved in nerve cell function. It helps regulate the electrical and chemical activity in the brain. One leading theory is that magnesium deficiency contributes to a phenomenon called cortical spreading depression a wave of intense nerve activity followed by a quiet period which is believed to underlie migraine auras and possibly trigger the cascade leading to migraine pain [5]. Low magnesium might make the brain "hyper-excitable," meaning neurons fire too easily or intensely, setting the stage for migraines. At adequate levels, however, magnesium has a calming, stabilizing effect on the nervous system. It can block or modulate certain neurotransmitters for instance, magnesium helps inhibit glutamate, an excitatory brain chemical that in excess can cause neurons to fire excessively [6]. Dr. Nada Hindiyeh, a neurologist with the American Headache Society, explains that migraines are thought of as a "hyper-excitable brain" disorder, and magnesium helps stabilize brain activity to prevent migraine triggers from cascading [6].

Magnesium also plays a role in muscle contraction and blood vessel tone. During a migraine attack, changes in blood vessels in the brain (constriction and dilation) are part of the pain process. Magnesium helps relax blood vessels and may improve blood flow, countering one aspect of migraine pathology. Additionally, magnesium has been shown to have anti-inflammatory and antioxidant effects, which could mitigate some of the inflammatory processes that occur during migraines [5].

Another interesting angle is hormonal: For women with menstrual migraines (migraines tied to the menstrual cycle), magnesium might be especially beneficial. This is because magnesium levels can fluctuate with hormonal changes. Some evidence suggests magnesium is particularly helpful in menstrual migraine possibly because magnesium levels tend to fall right before menstruation in some women [2]. By supplementing magnesium, those drops might be blunted, reducing trigger sensitivity.

It's important to note that measuring magnesium isn't straightforward. You can have normal magnesium levels on a standard blood test yet still have a functional deficiency in the brain or within cells. Experts point out that blood serum magnesium represents only 1-2% of the body's magnesium, and some migraine sufferers have normal blood magnesium but low magnesium inside cells (like in red blood cells or the brain) [5]. This "hidden" magnesium deficiency could be why a person with migraines might benefit from supplements even if routine labs look fine. In short, magnesium is vital for neurological stability, and a slight shortfall - especially in the brain - could tip the balance toward a migraine.

Because of these findings, many clinicians believe that correcting magnesium deficiency or using magnesium at higher levels might prevent migraines. Magnesium is viewed as a well-tolerated, safe and inexpensive option for migraine prevention by headache specialists [7]. It addresses a potential root cause (low magnesium and resulting neural hyper-excitability) rather than just treating symptoms. And unlike some prescription medications, magnesium isn't habit-forming and has a relatively benign side effect profile for most people. These advantages make it very appealing as a preventive strategy, especially for people seeking a more "natural" approach to migraine management.

Evidence: Does Magnesium Really Help Prevent Migraines?

It's clear that magnesium is important in the biology of migraines, but the crucial question is: if you take magnesium, will your migraines improve? Researchers have put this to the test in numerous studies. The good news is that a growing body of evidence suggests magnesium can indeed reduce the frequency and severity of migraines for some people though results can vary, and it's not a guaranteed cure-all.

Clinical trials on oral magnesium for migraine prevention date back to at least the 1990s. One of the landmark studies in 1996 found that giving migraine patients a high dose of magnesium (600 mg daily) significantly reduced the number of migraine attacks compared to placebo [8]. In that trial, about 41% of patients on magnesium had a reduction in migraine frequency by nearly half, a response rate much better than the placebo group [9][5]. This early evidence hinted that magnesium could be effective, and it prompted further research.

Since then, multiple randomized controlled trials (RCTs) and several reviews and meta-analyses have examined magnesium for migraines. A 2016 meta-analysis pooled results from 10 different trials of oral magnesium and concluded that magnesium significantly alleviated migraine frequency and intensity [9][5]. In statistical terms, patients taking magnesium had much lower odds of having a migraine attack compared to placebo (the meta-analysis reported odds ratios of ~0.20-0.27, indicating a substantial reduction in migraines) [9]. The researchers of that meta-analysis felt the evidence was strong enough to recommend magnesium (including intravenous magnesium for acute attacks and oral magnesium for prevention) as part of a "multimodal approach" to managing migraines [9].

Another comprehensive review in 2018 systematically evaluated clinical trials and concluded that magnesium provides a "Grade C" evidence level for migraine prevention - meaning it is possibly effective [8]. This review noted that at least one high-quality trial showed significant benefits of magnesium over placebo, and overall the data pointed to a real, if modest, preventive effect [8]. The authors highlighted that using a high dose of magnesium citrate (600 mg daily) was a safe, cost-efficient strategy for prophylaxis [8]. In plain language, they're saying: magnesium is cheap, generally safe, and it just might help reduce migraines so given the low downside, it's worth a try for many patients.

It's not all unequivocal, however. Some studies have failed to show a benefit, and a few reviews urge caution in interpreting the data. For instance, a 2019 meta-analysis that looked at vitamins and minerals for migraine (including magnesium) found the evidence inconclusive it stated that it's unknown if magnesium is effective for migraine prophylaxis due to insufficient high-quality data [10]. Likewise, a couple of smaller trials didn't find an advantage of magnesium over placebo [2]. Importantly, one of those negative studies used a form of magnesium that is poorly absorbed (magnesium oxide), leading experts to suspect the results might have been due to the form and absorption issues rather than magnesium being truly ineffective [2]. When that study is taken into account, reviews that average all results together can appear less positive. But when considering only well-absorbed forms (like magnesium citrate or magnesium sulfate IV) and adequate doses, the evidence tilts more in favor of benefit.

A recent 2025 review in the journal Nutrients summed it up well: "Accumulated evidence from case reports, case-control studies, observational studies, and randomized trials has shown the effectiveness of magnesium supplementation in alleviating migraine, both acutely and chronically." [5]. The same review discusses how three out of four systematic reviews and meta-analyses on the topic reported significantly positive results for magnesium, while the few that didn't were mostly saying that more data is needed (rather than outright refuting efficacy) [5]. In other words, most of the rigorous analyses have found at least some benefit from magnesium, and no major study has concluded that magnesium "doesn't work at all" rather, the worst that's been said is that we need larger trials to be sure of the extent of benefit [5].

What kind of improvements can migraine sufferers expect with magnesium? Clinical experience and studies suggest that magnesium is unlikely to completely eliminate migraines, but it often helps reduce the frequency of attacks or the severity of pain. For example, if someone usually gets eight migraine days per month, a successful course of magnesium might cut that down to five per month, or make some attacks milder. In research, a common benchmark is the "50% responder rate" - the proportion of patients who have their number of migraines cut in half. Magnesium often produces a notable 50% responder rate (in one study just over half of patients on magnesium achieved that reduction) [2], which is comparable to some prescription prophylactic drugs. Another study found magnesium supplementation reduced the number of migraine attacks by an average of 2.5 per month and decreased migraine days by about 1.7 days per month compared to placebo [11]. These are clinically meaningful improvements for chronic sufferers.

It's also worth mentioning that magnesium may work particularly well for certain subtypes of migraine. Evidence and expert opinion indicate that people who experience migraine with aura (the visual or sensory disturbances before a headache) and those with menstrual migraines might respond best to magnesium [6][2]. In fact, some headache specialists routinely recommend magnesium to patients with aura, given the mineral's role in calming the neural activity that sparks aura. Additionally, intravenous magnesium (given in hospitals) has proven effective at aborting acute migraine attacks, especially in patients who have aura or low magnesium levels. Emergency departments sometimes administer IV magnesium sulfate to migraine patients one meta-analysis found IV magnesium brought significant pain relief within 15-45 minutes for many patients in acute migraine status [9]. It's not a standard first-line acute treatment for all, but these acute results underscore that magnesium has real physiological effects against migraine mechanisms (particularly in those who may be deficient).

In summary, the evidence supports magnesium as a viable preventive treatment for migraines. It's not guaranteed to help everyone, but multiple studies and clinical guidelines consider it worth trying, given its safety. Even the most conservative reviews don't rule it out - they simply call for more research while acknowledging some patients do benefit [5]. Many neurologists and headache clinics (including the American Headache Society and UK's National Migraine Centre) include magnesium in their recommended toolkit for patients [6][2]. As the Migraine Trust (a UK charity) puts it, some supplements like magnesium have "some evidence of a benefit in migraine" and can be used alongside conventional treatments [3]. In the next sections, we'll cover how to use magnesium effectively for migraine prevention - focusing on the best form to take, how much to take, and how to do it safely.

Magnesium Citrate vs Other Forms: Choosing the Best Magnesium for Migraines

If you're considering magnesium supplements for migraine relief, you might be wondering: what is the best magnesium for migraines? Magnesium comes in many formulations, and not all are equal when it comes to absorption and tolerability. The short answer from experts is that magnesium citrate is often a top choice it's well-absorbed by the body and generally gentle on the digestive system. But let's break down the options.

Common forms of magnesium supplements include [3]:

  • Magnesium oxide - A widely available, inexpensive form. It has a high percentage of elemental magnesium per pill, but it's poorly absorbed in the gut. This means you get less magnesium into your bloodstream, and the rest stays in the intestines where it can cause loose stools. Magnesium oxide has been used in migraine studies (due to its availability), but its absorption issues may limit effectiveness for some.
  • Magnesium citrate - Magnesium bound with citric acid. This form is well absorbed and more bioavailable than oxide. It also has a mild laxative effect (citrate draws water into intestines), but typically less so than oxide. Magnesium citrate is frequently recommended for migraines - successful clinical trials used magnesium citrate at 600 mg daily [2].
  • Magnesium glycinate - Magnesium bound to the amino acid glycine. This form is known for being gentle on the stomach with minimal laxative effect. It's also well absorbed. Many people who get diarrhea from other forms find glycinate much easier to tolerate [3].
  • Magnesium hydroxide - Another common form (found in "milk of magnesia"). It's not as well absorbed and can cause diarrhea similar to oxide [3].
  • Magnesium sulfate - Available in oral form (Epsom salts) but more commonly used as an intravenous form (the IV solution of magnesium sulfate is what hospitals give for severe asthma, pre-eclampsia, or migraine). Orally, it's very laxative (Epsom salt is a potent laxative), so it's not used as a daily supplement for migraine prevention.

Other forms you might encounter include magnesium malate, taurate, orotate, threonate, etc. These are less studied specifically for migraines but generally offer varying absorption profiles. Magnesium malate and magnesium taurate are also considered well-absorbed and gentle, whereas magnesium L-threonate is a newer form touted for brain health (it crosses the blood-brain barrier more readily) - though evidence for migraines is anecdotal at best.

So, which to choose? Magnesium citrate strikes a good balance for migraine purposes. The National Migraine Centre notes that the successful studies in migraine prevention used magnesium citrate at 600 mg daily, and they describe it as a "reasonably well-absorbed" form [2]. Citrate is also readily available in the UK over the counter. Meanwhile, The Migraine Trust suggests that forms like magnesium oxide may be more likely to cause stomach upset and diarrhea, because they're less easily absorbed, whereas forms like magnesium glycinate have better absorption and fewer side effects [3]. In other words, bioavailability matters - a form that dissolves well and gets taken up into the body will deliver more migraine-fighting magnesium to your system, while causing less intestinal distress.

For many migraine sufferers, the primary side effect to watch out for with magnesium is diarrhea or loose stools. If you experience this, it doesn't mean you have to abandon magnesium - it might mean you should switch the form or adjust the dose. Often, switching from magnesium oxide (or another laxative form) to magnesium citrate or glycinate can markedly reduce GI side effects [3][2]. Every individual is different: some find citrate works great, while others prefer glycinate. It can be worth trying different types to see which your body tolerates best [3]. Magnesium citrate is a strong starting candidate given its track record in trials and good absorption, making it arguably one of the best magnesium forms for migraines.

Another consideration is combination supplements. Some products combine magnesium with other purported migraine helpers (for example, magnesium plus vitamin B2 (riboflavin) and CoQ10, which are also supplements with migraine evidence). There's even a prescription combination available in some countries that pairs magnesium, B2, and CoQ10. While combination pills can be convenient, it's often fine to take magnesium alone and get those others separately if needed. Magnesium itself should have a chance to show its benefit when used at the right dose.

Finally, remember that dietary sources of magnesium are important too. Even if you supplement, eating magnesium-rich foods supports overall levels and health. Foods high in magnesium include leafy green vegetables (like spinach, kale), nuts and seeds (almonds, pumpkin seeds, cashews), legumes (beans, lentils), whole grains, avocados, bananas, and even dark chocolate. While you likely can't eat enough spinach to equal 600 mg of magnesium every single day (that would be a lot of spinach!), a diet rich in these foods can complement your supplement and provide other health benefits. Plus, a healthy diet supports better migraine control in general. The NHS advises migraine patients to eat regular meals, stay hydrated, and avoid trigger foods as part of lifestyle management [1]. Adding magnesium-rich foods is one more positive step in that direction.

Dosage and Tips: How to Take Magnesium for Migraine Prevention

One of the most common questions is: How much magnesium should I take for migraines? Getting the dosage right is key too little might not help, and too much can cause diarrhea. Experts typically recommend a daily dose in the range of 400 mg to 600 mg of elemental magnesium for migraine prevention [3][12]. This "elemental" magnesium refers to the actual magnesium content, not the total weight of the compound. (For example, a 1000 mg magnesium citrate tablet might contain ~160 mg of elemental magnesium - always check the label for elemental magnesium). To see a practical example, this high-quality magnesium citrate provides a precisely measured dose per capsule, making it easier to follow the daily recommendations.

The 400-600 mg/day recommendation is a bit above the standard daily nutritional requirement for magnesium (which for adults is around 300-400 mg). The reason for the higher dose is that therapeutic studies in migraines have found benefit at these higher levels. The Migraine Trust notes that guidelines for doctors often suggest 400-600 mg daily to help with migraine, which is more than normal dietary intake [3]. For instance, NHS Highland's headache clinic and other UK specialists frequently advise around 600 mg daily for adults with migraine (often split into two doses of 300 mg each). In the US, the American Headache Society similarly recommends around 400-500 mg daily for migraine prevention [6]. In short, about 0.4-0.6 gram of magnesium per day is the target range for adults, unless directed otherwise by a doctor.

Here are some practical tips for supplementing with magnesium citrate effectively for migraines:

  • Start low and go slow: If you jump straight to a high dose (600 mg) you may get diarrhea or stomach cramps. It's often wise to start with a lower dose (e.g. 200 mg once daily) and gradually increase to the full dose over a couple of weeks [2]. This allows your body to adjust.
  • Split the dose: Taking smaller doses multiple times a day improves absorption and reduces GI side effects. For example, instead of 600 mg once, you could do 300 mg in the morning and 300 mg in the evening, or even 200 mg three times a day [2]. Many find divided doses with meals are gentler on the stomach.
  • Take it with food: Magnesium can be taken with meals to improve absorption and tolerance. Having food in your stomach can reduce the chance of loose stools that magnesium might cause on an empty stomach [3].
  • Stay hydrated: Magnesium draws water into the intestines, so counteract this by drinking adequate water through the day. Good hydration also itself can help ward off headaches.
  • Be consistent: Natural remedies for migraine like magnesium don't work overnight. Give it time - at least 2 to 3 months - to gauge efficacy [2]. Migraines often follow cycles, so you need a few months to see if the frequency pattern improves with magnesium.
  • Use a headache diary: Track your migraine days and severity while on magnesium [2]. This can be a simple diary or an app. Seeing the trend over a few months will help you determine if magnesium is helping (e.g. "I went from 8 migraine days a month to 4 per month after three months of magnesium"). The act of tracking also helps you identify any other changes or triggers in your life.
  • Find the right formulation: If magnesium citrate at a high dose still causes unacceptable diarrhea, consider switching to magnesium glycinate, or another form as discussed earlier. The best magnesium for migraines is ultimately the one you can take regularly without issues. Magnesium citrate is less likely to cause diarrhea than magnesium oxide, but individuals vary [2].
  • Consider timing: Some people take magnesium at night, as it can have a calming effect and even aid sleep for some (magnesium is sometimes used for insomnia). If nighttime dosing doesn't upset your stomach, this could be a bonus. However, magnesium doesn't generally cause drowsiness, so you can take it at any time that fits your routine.
  • Don't give up too early: If you experience mild side effects, try the above adjustments (lower dose, different form, split dosing). Often, these tweaks can solve the issue. If one form of magnesium doesn't suit you, another might. It often takes experimentation to find what works best for your body, but many patients do find a regimen they can stick with.

It's worth reiterating that improvement is usually gradual. You might notice after a month that you've had one or two fewer migraines, or slightly less intense pain - that's a great sign to continue. By three months, the change can be clearer. Some people who respond to magnesium call it a "game-changer" for their migraines, while others might get a mild benefit or unfortunately no change. The only way to know is to try, track, and communicate with your doctor about what you're experiencing.

A Note on Magnesium Dose in Special Situations

  • Pregnancy: Pregnancy can sometimes exacerbate migraines (though some women find their migraines improve during pregnancy). Magnesium is one of the few preventive options considered safe for use in pregnancy - in fact, obstetricians sometimes recommend magnesium for pregnant women for other reasons like leg cramps or high blood pressure. The Migraine Trust notes that magnesium (and riboflavin) are considered safe to take during pregnancy, though you should always consult your doctor for an appropriate dose [3]. Often, a lower dose (e.g. 200-300 mg daily) might be advised initially for pregnant women to be extra cautious, even though higher doses are likely fine. Always get personalized medical advice in this scenario.
  • Children and adolescents: Migraines can affect children and teens as well. Supplements can be considered for them, but the doses will be lower based on body weight, and it should be done under medical supervision [3]. A pediatrician or neurologist can guide you on safe dosing (for instance, a common pediatric dose might be around $10~mg/kg$ of body weight per day, not to exceed ~400 mg).

Safety, Side Effects, and Precautions

One of the big advantages of magnesium over typical prescription migraine drugs is its benign safety profile. Magnesium is a nutrient your body knows how to handle, and when taken at sensible doses it doesn't cause the kind of systemic side effects that many medications do. There are no sedation effects, cognitive side effects, or habit-forming risks with magnesium. It also doesn't cause medication-overuse headache (a concern with frequent painkiller or triptan use). That said, it's important to use magnesium supplements wisely and be aware of a few potential issues:

  • Digestive Side Effects: As discussed, the main side effect of magnesium supplementation is loose stools or diarrhea. You might also experience minor stomach cramping or bloating. These effects happen because unabsorbed magnesium in the intestines draws water in and stimulates bowel activity. In fact, certain magnesium salts (like magnesium hydroxide) are sold as laxatives. To minimize GI upset, use a well-absorbed form (citrate or glycinate), split the dose, and take with food. If diarrhea occurs, reduce your dose temporarily and increase more gradually. Many people find these symptoms subside after the body adjusts over a couple of weeks. Severe diarrhea or vomiting from magnesium is rare at migraine-treatment doses; if it occurs, stop the supplement for a day or two to recover, and reintroduce more gently (or talk to your doctor about trying a different approach).
  • Interaction with Medications: Magnesium can interact with a few medications. It can enhance the effects of blood pressure-lowering drugs (since magnesium itself can lower blood pressure slightly by relaxing blood vessels) [2]. If you are on antihypertensives, keep an eye on your blood pressure when adding magnesium - it's not usually a problem, but theoretically the combination could make you feel lightheaded if your pressure gets too low. Magnesium can also interfere with the absorption of certain antibiotics (like tetracyclines and fluoroquinolones) and thyroid medications if taken at the same time [2]. The solution is usually simple: separate magnesium and those medications by 2-4 hours so they don't compete in the gut. It's always wise to let your GP or pharmacist know you are taking magnesium, so they can check for any personal medication interactions.
  • People with kidney issues: Magnesium is excreted by the kidneys. If you have chronic kidney disease or any condition that impairs kidney function, high-dose magnesium supplements could accumulate and cause problems. Thus, such individuals should only use magnesium under medical advice, or may need dose adjustments. For those with normal kidney function, excess magnesium is usually efficiently eliminated in urine (one reason magnesium supplements are safe is that your body will generally get rid of what it doesn't need up to a point).
  • Allergic reactions: True allergy to magnesium salts is extremely rare (magnesium is an element found in us, after all). Inert ingredients in tablets could theoretically cause reactions in susceptible individuals (e.g. fillers). If you have multiple chemical sensitivities or allergies, choose a supplement with minimal additives.
  • Magnesium overdose: Magnesium supplements can cause toxicity only if taken in huge amounts or if you have kidney failure. Symptoms of too much magnesium (hypermagnesemia) include very low blood pressure, confusion, irregular heartbeat, or even coma - but this is virtually only seen in people with kidney failure or in cases of excessive IV magnesium. The doses we're discussing ($400-600~mg/day)$ are far below toxic levels for someone with normal kidneys. To put in perspective, the European Food Safety Authority set the upper level for supplemental magnesium at $400~mg/day$ to avoid diarrhea, but not because of systemic toxicity. Some individuals (e.g. constipated people or pre-eclampsia patients) have taken grams of magnesium under supervision. As long as you stick to recommended doses and have normal renal function, magnesium is exceedingly safe.
  • Pregnancy and breastfeeding: As mentioned, magnesium is relatively safe in pregnancy - it's even given intravenously for severe pre-eclampsia at much higher doses. Just run your plan by your healthcare provider to personalize it. Breastfeeding mothers can also take magnesium supplements; magnesium will pass into breast milk, but not in harmful amounts. In fact, postpartum women who are breastfeeding and sleep-deprived might benefit from magnesium's stress-reducing effects (magnesium can support relaxation and muscle recovery).

Overall, the safety profile of magnesium is excellent, especially compared to typical migraine prescription drugs that can cause side effects ranging from cognitive fog and weight gain (in the case of some anti-epileptic drugs) to tingling and memory issues (with some other preventives). Magnesium's main "side effect" of loose stools is manageable and non-dangerous. The key is to manage supplementation intelligently use a good form, correct dose, and integrate it into your routine in a sustainable way.

One precaution: keep magnesium supplements out of reach of young children. Because flavored magnesium gummies or powders might taste like candy, a child could ingest a large amount and get a very unpleasant diarrhea bout (or more severe effects). As with any supplement or medicine, safe storage is important.

Combining Magnesium with Other Treatments for Migraine Relief

Magnesium works best as one component of a comprehensive migraine management plan. Think of it as one tool in your toolkit very useful, but not the only one. Many people will use magnesium alongside conventional treatments and other lifestyle measures for optimal migraine control. This combined approach is actually encouraged by headache specialists. The National Migraine Centre notes that you can take supplements like magnesium in addition to your prescribed migraine medications, and some people find the combination helps more than either approach alone [3]. There's no pharmacological conflict in using magnesium with painkillers or triptans; in fact, some evidence suggests magnesium might even enhance the effectiveness of certain migraine medications [2] (for example, by aiding relaxation or improving cell energy metabolism).

Here are a few ways to integrate magnesium into a broader plan:

  • Acute Migraine Care: Continue to use your acute treatments (such as sumatriptan or ibuprofen) as needed when migraines strike. Magnesium won't abort a migraine already in progress (unless given intravenously at a clinic), so you'll still want your rescue medications or strategies. Some patients do take an extra dose of oral magnesium at migraine onset hoping for relief, and while this is not a proven acute treatment, it's benign enough to try (at worst, you'll get some laxative effect later). The primary role of oral magnesium, however, is prevention.
  • Other Supplements: Magnesium is often mentioned in the same breath as riboflavin (vitamin B2) and Coenzyme Q10 - two other supplements with evidence for migraine prevention. There is no harm in taking these together if desired. For instance, a common regimen is: magnesium 400 mg + riboflavin $400~mg+CoQ10~100$ mg daily. Each addresses migraine via different theoretical mechanisms (riboflavin and CoQ10 aid mitochondrial energy in brain cells, which might reduce migraine susceptibility [3]). Some patients add feverfew or omega-3 fish oil as well, which have a bit of supportive evidence [3][2]. All these can generally be combined safely - but introduce them one at a time, so you can tell what's working or if something causes side effects.
  • Prescription Preventives: If you are on a preventive medication like propranolol, amitriptyline, or topiramate, you can still use magnesium. There's no known negative interaction; in fact, some neurologists incorporate magnesium as part of a multi-pronged preventive regimen (especially if the prescription drug alone isn't giving full relief). Always inform your doctor of everything you're taking, but magnesium is unlikely to change the effectiveness of your migraine drugs (aside from the caution with blood pressure meds as noted). If magnesium works well, in some cases patients have been able to reduce or eliminate other preventives under doctor guidance - but do this only with medical advice. It's simply an option down the line if the natural route proves very effective for you.
  • Lifestyle and Trigger Management: Magnesium supplementation should go hand-in-hand with the classic lifestyle advice for migraines. The NHS and migraine charities stress maintaining a regular routine: consistent sleep patterns, not skipping meals, staying hydrated, managing stress, and getting moderate exercise [1][3]. Magnesium actually might aid some of these - for example, it can improve sleep quality in some individuals and has a calming effect that might make stress management a bit easier. It's not a replacement for healthy habits, but it can support them. Additionally, try to identify your migraine triggers (common ones include certain foods, alcohol, caffeine withdrawal, strong odors, or flashing lights). Reducing exposure to triggers combined with magnesium's increased threshold for attacks could together significantly cut your migraine frequency.
  • Consultation and follow-up: Since magnesium is available over-the-counter, many people start it on their own. But do loop in your healthcare provider, especially if you have a chronic migraine condition. A GP or neurologist will be interested to hear that you're trying magnesium - it signals you're taking initiative, which most doctors appreciate. They may have additional tips or might want to monitor your progress. For example, after 3-6 months of magnesium use, you could check in with your doctor to evaluate how much your migraine frequency has changed and discuss whether to continue the supplement or make any adjustments. In the UK, while magnesium isn't (yet) an official part of NHS migraine treatment protocols, GPs are generally aware of its use. Some NHS clinics provide patient leaflets mentioning magnesium and other supplements as an option to consider for prevention [14].

Finally, a special scenario: if you need urgent migraine relief (for instance, a status migrainosus attack that won't break), seek medical help. In an urgent care or hospital setting, mention if you're a candidate for IV magnesium. Because IV magnesium sulfate can rapidly treat an acute migraine, especially if you have aura or neurological symptoms, a doctor might administer it as part of your acute treatment plan [9]. This doesn't interfere with your home regimen - it's a one-time boost that might abort a nasty attack.

UK Perspective: What Do the NHS and Experts Say?

It's important to frame magnesium usage in the context of UK healthcare guidance. While magnesium supplements are not a frontline prescription in NHS migraine guidelines, they are recognized by headache specialists and organizations as a helpful complementary approach. The NHS website's section on migraines currently emphasizes pharmaceuticals and lifestyle changes for prevention, but NHS resources do acknowledge supplements like magnesium and vitamin B2 as possible preventive measures for patients interested in complementary therapies [4]. NHS Inform (the patient information service in Scotland) specifically lists magnesium as a supplement that "might help to prevent your migraine symptoms," alongside riboflavin [4]. This reflects a growing openness to non-pharmacological options.

Furthermore, UK-based research organizations and charities have shown interest in magnesium. The National Institute for Health Research (NIHR) has noted the need for more studies on nutraceuticals (including magnesium) for migraine, which means future NHS guidance could incorporate such approaches if evidence solidifies. In practice, many GPs in the UK are already informally supportive of patients trying magnesium, given its safety. It's not uncommon for a GP to say, "It's not officially in our protocol, but some of my patients have found magnesium helpful - you could give it a go."

The Migraine Trust, a leading UK migraine charity, provides detailed information on supplements and states that magnesium "may reduce frequency and severity of migraine attacks for some people" [3]. They even note that UK clinical guidelines for managing headaches include riboflavin as a potential treatment, and that guidelines for doctors often recommend 400-600 mg of magnesium for migraine (even if evidence is limited) [3]. This shows that within the headache specialist community, magnesium is a well-accepted option. The Migraine Trust and National Migraine Centre both publish guidance encouraging patients to discuss supplements like magnesium with their doctors and to ensure they source supplements from reputable outlets (pharmacies or established brands) [3][2]. Notably, these organizations stress checking with your GP or specialist before starting a supplement a sensible step to make sure it's safe for you and won't interfere with anything else [3].

In summary, the UK view on magnesium for migraines can be described as cautiously optimistic. It's cautious because healthcare authorities await more definitive research and because supplements are not regulated as medications, but it's optimistic because many UK experts recognize the potential benefit and low risk. Magnesium is increasingly mentioned in patient education materials in the UK, and numerous British migraine sufferers report positive experiences with it. It aligns with a broader movement towards integrating lifestyle and nutritional strategies into chronic disease management something the NHS has been embracing more in recent years under initiatives for self-care and holistic care.

Conclusion: A Natural Ally in the Fight Against Migraines

Living with chronic migraines can be overwhelming, but it's encouraging to know there are multiple strategies to reclaim some control and magnesium supplementation is one such strategy. Research and clinical experience have shown that magnesium (especially in the well-absorbed citrate form) can act as a safe, natural prophylactic, potentially reducing how often migraines strike and how intense they become. For many UK patients and others worldwide, adding magnesium to their migraine toolkit has provided noticeable relief and an empowering sense that they can take action beyond just waiting for the next headache.

To recap the key points:

  • Magnesium matters in migraines: Migraine sufferers are often low in magnesium, and this mineral is vital for stabilizing nerve cells, regulating blood vessel tone, and preventing the chain reactions in the brain that lead to migraine attacks [5]. By correcting a possible deficiency, magnesium addresses migraine at its roots as a natural remedy for migraine relief.
  • Evidence supports use: Clinical studies and reviews indicate that magnesium supplementation (around 400-600 mg daily) can significantly cut migraine frequency for some individuals, with minimal risks [9][8]. Even though not every study showed a benefit, the overall trend is positive, and headache experts consider it a recommended magnesium therapy for migraines as part of an integrative approach [6][3].
  • Magnesium citrate is a top choice: Thanks to its good absorption and tolerability, magnesium citrate is often deemed the best magnesium for migraines among supplement forms. Trials that succeeded in preventing migraines have used magnesium citrate 600 mg daily [2]. Other forms like glycinate are also excellent alternatives if needed.
  • Patience and proper dosing are crucial: Magnesium isn't an overnight fix. It should be taken consistently for a few months, at the right dose, to gauge its benefit. Titrating the dose, splitting it, and taking with food can help avoid side effects like diarrhea [2][3]. Most people can find a regimen that their body accepts.
  • Safety is a strong point: Magnesium has a far gentler side effect profile than many drugs - по sedation, no cognitive impairment, and it's safe for long-term use. Side effects are mostly limited to the gastrointestinal tract and can be managed. It's one of the few preventive interventions that is even considered safe during pregnancy (with appropriate medical guidance) [3].
  • Holistic migraine care: Magnesium works best when combined with other healthy practices - be it maintaining regular sleep and meals, managing stress, staying hydrated, or even pairing magnesium with other supplements or medications as needed. It's not an either/or scenario; you can pursue natural migraine remedies like magnesium and use prescribed treatments together for a synergistic effect [3].
  • Consultation and personalization: Always loop in your healthcare provider about supplement use. In the UK, doctors are generally supportive of patients trying magnesium for migraines, and they can offer valuable input (or at least ensure there's no contraindication in your specific case). They can also help track your progress and incorporate this into your overall migraine management plan.

Remember, every person's migraine condition is a bit different - some trial and error is normal in finding what works for you. For chronic migraine sufferers in the UK and beyond, magnesium citrate offers a ray of hope. It exemplifies the concept of using a simple, natural nutrient as a remedy to improve a complex condition. While it may not eradicate migraines completely, it could be the difference between having migraines rule your week versus you having more migraine-free days to enjoy life. Given its safety, accessibility, and the scientific rationale behind it, magnesium supplementation is a prudent option to consider on your journey toward better migraine control.

Before starting any new supplement, have a quick chat with your GP, especially if you have other health conditions or take other medications. Buy your magnesium from a reputable UK pharmacy or supplement brand to ensure quality [3], and always check the label for the elemental magnesium content to dose correctly. Then, armed with your magnesium and a bit of patience, observe the changes. You just might find that this humble mineral becomes your powerful ally in managing migraines.

In the end, fighting migraines often requires a multi-faceted approach. Magnesium is one piece of the puzzle a natural, evidence-backed remedy you can easily integrate. For many, it's been a game-changer. As one might say, it's about "magnesium for migraines" in action: using the calming power of this mineral to reclaim calmer days from the grip of migraine attacks. Here's to hoping that with the help of magnesium, you'll experience fewer migraines, gentler headaches, and the relief you deserve.

Sources

  1. National Health Service. Migraine [Internet]. London: NHS; Page last reviewed 2022 Sep 15; Next review due 2025 Sep 15 [cited 2025 Jun 9]. Available from: https://www.nhs.uk/conditions/migraine/
    [Back to text]

  2. National Migraine Centre. ‘Natural’ remedies for headache [Internet]. London: National Migraine Centre; [date unknown] [cited 2025 Jun 9]. Available from: https://www.nationalmigrainecentre.org.uk/understanding-migraine/factsheets-and-resources/natural-remedies/
    [Back to text]

  3. The Migraine Trust. Supplements for migraine [Internet]. London: The Migraine Trust; Last reviewed 2025 Jan [cited 2025 Jun 9]. Available from: https://migrainetrust.org/live-with-migraine/healthcare/treatments/supplements/
    [Back to text]

  4. NHS inform. Migraine treatment and prevention [Internet]. Glasgow: NHS inform; 2024 Sep 25 [cited 2025 Jun 9]. Available from: https://www.nhsinform.scot/illnesses-and-conditions/brain-nerves-and-spinal-cord/migraine-treatment-and-prevention/
    [Back to text]

  5. Dominguez LJ, Veronese N, Sabico S, Al-Daghri NM, Barbagallo M. Magnesium and migraine. Nutrients. 2025;17(4):725. DOI: https://doi.org/10.3390/nu17040725.
    [Back to text]

  6. American Headache Society. Incorporating nutraceuticals for migraine prevention [Internet]. Mount Royal (NJ): American Headache Society; 2021 Apr 15 [cited 2025 Jun 9]. Available from: https://americanheadachesociety.org/news/incorporating-nutraceuticals-for-migraine-prevention
    [Back to text]

  7. Yablon LA, Mauskop A. Magnesium in headache. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011 [cited 2025 Jun 9]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507271/
    [Back to text]

  8. von Luckner A, Riederer F. Magnesium in migraine prophylaxis—is there an evidence-based rationale? A systematic review. Headache. 2018;58(2):199–209. DOI: https://doi.org/10.1111/head.13202.
    [Back to text]

  9. Chiu HY, Yeh TH, Huang YC, Chen PY. Intravenous and oral magnesium for treating migraine: a meta-analysis of randomized controlled trials. Pain Physician. 2016;19(1):E97–E112. [Internet]. [cited 2025 Jun 9]. Available from: https://www.painphysicianjournal.com/current/2016/january/2016;19;E97-E112.pdf
    [Back to text]

  10. Okoli C, O’Gorman C, D’Souza M, McVinney L. Vitamins and minerals for migraine prophylaxis: a systematic review and meta-analysis. Can J Neurol Sci. 2019;46(3):266–277. DOI: https://doi.org/10.1017/cjn.2019.29.
    [Back to text]

  11. Parikh SK, Silberstein SD. Effects of selected dietary supplements on migraine prophylaxis. Neurol Sci. 2024;45(8):3449–3461. DOI: https://doi.org/10.1007/s10072-024-07739-1.
    [Back to text]

  12. American Migraine Foundation. Magnesium and migraine [Internet]. 2021 Oct 20 [cited 2025 Jun 9]. Available from: https://americanmigrainefoundation.org/resource-library/magnesium/
    [Back to text]

  13. Mauskop A, Varughese J. Why all migraine patients should be treated with magnesium. J Neural Transm. 2012;119(5):575–579. DOI: https://doi.org/10.1007/s00702-012-0790-2.
    [Back to text]

  14. University Hospital Southampton NHS Foundation Trust. Treatments for frequent, severe headaches and migraines (Patient Information Leaflet) [Internet]. Southampton (UK): University Hospital Southampton NHS Foundation Trust; 2020 Aug. Version 3 [cited 2025 Jun 9]. Available from: https://www.uhs.nhs.uk/Media/UHS-website-2019/Patientinformation/Brain-and-spine/Treatments-for-frequent-severe-headaches-and-migraines-2368-PIL.pdf
    [Back to text]



Product Related to This Article


Related Articles on Magnesium

Back to blog

Leave a comment

Please note, comments need to be approved before they are published.